Description:
We are looking for a hands-on, detail-oriented Research Associate (RA) or Senior Research Associate (SRA) to join our preclinical research team. You will assist our in vivo cell engineering programs by performing critical procedures such as injection of therapeutic agents, animal health monitoring, sample collection, imaging, and ex vivo analysis. Title and compensation will be commensurate with education and experience.
KEY RESPONSIBILITIES
- Multi-route dosing: Administer cell therapies and nanoparticles via IV (tail vein), IM, SC, and RO routes.
- Bleeding and sample collection: Conduct retro-orbital, submandibular, and tail vein bleeds; collect tissues and organs at study timepoints.
- Humanized mouse models: Generate and maintain PBMC-engrafted and CD34 HSPC-engrafted NSG models; monitor engraftment and immune reconstitution.
- Animal health monitoring: Perform clinical observation scoring, body weight, tumor measurements, and welfare checks per IACUC SOPs.
- In Vivo and Ex vivo analysis: Perform live animal IVIS imaging. Process blood and tissues/organs for flow cytometry, cytokine profiling, and immune phenotyping.
- Downstream analysis: Perform multi-colored flow cytometry analysis of homogenized tissues.
- Documentation: Maintain accurate ELN entries, animal records, and IACUC compliance logs; update SOPs as needed.
- Collaboration: Partner with Immunology, Cell Therapy, and Delivery teams; communicate timelines and results clearly.
- Vivarium operations: Support animal supply management, colony records, and vivarium upkeep.
QUALIFICATIONS AND REQUIREMENTS
- Education: BSc and at least 4 years of hands-on in vivo experience.
- Dosing routes: Proficient in at least three of: IV, IM, SC, and RO in rodents.
- Health monitoring: Skilled in clinical scoring, body weight tracking, and humane endpoint assessment.
- Imaging: Experience in both live animal and ex vivo organ IVIS imaging
- Bleeding: Competent in at least two bleeding techniques (retro-orbital, submandibular, or tail vein).
- Immunology foundation: Working knowledge of immune cell biology and standard assays (flow cytometry, ELISA).
- Organization: Meticulous record-keeping with strong attention to detail and scientific rigor.
- Communication: Effective communicator; collaborative team player in a fast-paced environment.